Cisplatin and electrolyte abnormalities

Author: tcly

August undefined, 2024

Web• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... WebNov 1, 2024 · Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia, hypocalcemia and hyponatremia.

Renal and electrolyte disturbances associated with cisplatin

WebMay 7, 2024 · For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the … WebNov 1, 2024 · Vaughn E. Dobalian Abstract and Figures Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia,... fitzwilliam hotel belfast menu

Cisplatin dosing, indications, interactions, adverse effects

WebAug 26, 2024 · Electrolyte disturbances can be caused by infections, medicines, trauma and surgery; poor nutritional intake and malabsorption can also contribute to deficiencies [3] . The exact incidence of electrolyte disturbances in the UK is difficult to define, as individual studies have tended to focus on the occurrence in discrete populations [4,5] . WebUse Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. ... Additive: etoposide w/ cisplatin & KCl(?), imipenem-cilastatin (may be used for shorter periods), meropenem (may be used for shorter periods) ... WebAug 18, 2024 · Mannitol, given as a hypertonic solution, is primarily used in the treatment of cerebral edema and glaucoma. Although generally well tolerated, a variety of fluid, electrolyte, and kidney complications can occur if the patient is not carefully monitored. (See "Evaluation and management of elevated intracranial pressure in adults", section on ... can i make cheese sauce with oat milk

Electrolyte Imbalance - Managing Side Effects - Chemocare

Hypomagnesemia - Endocrine and Metabolic Disorders - Merck …

WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. … WebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic … fitzwilliam hotel belfast websiteWebSep 1, 2024 · Cisplatin for injectioncan cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms have … fitzwilliam hotel rotherham

"WebPlatelets <50000 Neutrophils <500 Renal Impairment CrCl 41-59 mL/min: 250 mg/m² IV on day 1 CrCl 16-40 mL/min: 200 mg/m² IV on day 1 CrCl <15 mL/min: Not recommended Hepatic Impairment Dose... " - Cisplatin and electrolyte abnormalities

Cisplatin and electrolyte abnormalities

Cisplatin-induced renal toxicity in elderly people - PubMed

WebIn patients with gynecologic cancers, treated with cisplatin or cisplatin in combination with paclitaxel, a higher incidence of nephrotoxicity in the combination group was noted. 414 In addition, ... Electrolyte abnormalities that may either increase the toxicity of concomitant agents (hypokalemia in patients receiving digoxin) or may be ... WebJun 24, 2024 · Electrolyte abnormalities (hypokalemia, hypophosphatemia, and hypomagnesemia) Electrolyte abnormalities were defined as ≥ grade 1 hypokalemia, …

Did you know?

Webelectrolyte imbalance (hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia ... (with abnormalities of the fasting and 2-hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus has been reported. ... There is a risk of ototoxic effects if cisplatin and LASIX are given concomitantly. In addition, WebDec 15, 2024 · An electrolyte imbalance occurs when your body’s mineral levels are too high or too low. This can negatively affect vital body systems. Electrolytes must be evenly balanced for your body to...

WebAbstract Cisplatin is a widely used platinum‐based chemotherapy agent. Its common adverse effects are neuropathy, nephrotoxicity, electrolyte abnormality, and rarely causing thrombotic vascular toxicity. We present a patient known to have small‐cell lung cancer who developed ischemic cerebrovascular accident (CVA) after receiving ... WebCertain medications may cause an electrolyte imbalance such as: Chemotherapy drugs (cisplatin) Diuretics (furosemide [Lasix] or bumetanide [Bumex]) Antibiotics (amphotericin B) Corticosteroids (hydrocortisone) Symptoms of Electrolyte Imbalance: As described, an electrolyte imbalance may create a number of symptoms.

WebFrequent grade 3 or 4 adverse events included fatigue, dyspnea, leukopenia, thrombocytopenia, and electrolyte abnormalities. No objective responses were observed; 5 (50%) of 10 patients treated at the MTD had stable disease. Pharmacokinetics indicated an oral triapine bioavailability of 88%. WebMay 24, 2006 · Conclusion: Cisplatin can cause permanent nephrotoxicity, including Gitelman-like syndrome. This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Publication types Case Reports Review MeSH terms Adult Alkalosis / chemically induced* Antineoplastic Agents / adverse effects*

Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage …

WebMagnesium depletion usually results from inadequate intake plus impairment of renal conservation or gastrointestinal absorption. There are numerous causes of clinically significant magnesium deficiency (see table Causes of Hypomagnesemia Causes of Hypomagnesemia ).Hypomagnesemia is common among hospitalized patients and … can i make chapatis with plain flourWebNational Center for Biotechnology Information fitzwilliam house dental practiceWebJun 8, 2024 · Cisplatin, the active ingredient in Cisplatin injection, is a yellow to orange crystalline powder with the molecular formula Cl 2 H 6 N 2 Pt and a molecular weight of 300.05. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. can i make ceviche ahead of timeWebHypomagnesemia may cause nausea, vomiting, sleepiness, weakness, personality changes, muscle spasms, tremors, and loss of appetite. If severe, hypomagnesemia can cause seizures Seizure Disorders In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many … fitzwilliam hotel waterfordWebSep 18, 2024 · NCBI Bookshelf fitzwilliam hotel belfast gymWebJun 24, 2024 · Cisplatin-induced nephrotoxicity mainly manifests as kidney tubular injury leading to electrolyte disturbances manifested as hypomagnesemia, hypokalemia, and hypophosphatemia and/or increased serum creatinine (occurring more than 7 days after treatment initiation) and decreased glomerular filtration rate [ 8, 9 ]. fitzwilliam hotel waterford irelandWebOct 19, 2024 · Severe electrolyte abnormalities during cisplatin were associated with having 2–6-month CKD or hypertension (adjusted odds ratio (AdjOR) [95% CI]: 2.65 [1.04–6.74]). Having both AKI and severe electrolyte abnormalities was associated with 2–6-month hypertension (AdjOR [95% CI]: 3.64 [1.05–12.62]). Conclusions fitzwilliam institute moodle