Cisplatin and sodium thiosulfate

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August undefined, 2024

WebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied … WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral …

Sodium Thiosulfate Administered Six Hours after Cisplatin Does …

WebJun 21, 2024 · The 3-year rate of overall survival was 98% (95% CI, 88 to 100) among children in the cisplatin–sodium thiosulfate group and … WebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in-vivo models of myocardial IR as both preconditioning and post conditioning agent (Ravindran and Kurian 2024a ). rcss christmas trees

Effects of sodium thiosulfate versus observation on development …

Webcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … WebA randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer. J Otolaryngol Head Neck Surg . 2024;48(1):4. doi: 10.1186/s40463-019-0327-x PubMed Google Scholar Crossref WebSep 9, 2024 · Sodium thiosulfate is a type of medication used to treat cyanide poisoning and to help lessen the side effects from cisplatin. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. sims school sign up

Transtympanic Sodium Thiosulfate for Prevention of Cisplatin

Hear Me Out: Mitigating Cisplatin-Induced Ototoxicity

WebJan 31, 2024 · PEDMARK® (sodium thiosulfate injection) PEDMARK ® is the first and only U.S. Food and Drug Administration (FDA) approved therapy indicated to reduce the risk of ototoxicity associated with... WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. sims school optionsWebMar 29, 2024 · An important step forward in addressing this was the recent approval of intravenous sodium thiosulfate by the US Food and Drug Administration to treat ototoxicity in pediatric patients with localized, nonmetastatic solid tumors. 11 However, for adult patients, there are no currently approved therapies for cisplatin-induced ototoxicity. Until ... rcs school rawmarsh

"WebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium … " - Cisplatin and sodium thiosulfate

Cisplatin and sodium thiosulfate

Fennec Pharmaceuticals Announces PEDMARK® (sodium

WebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below … WebThe chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced …

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WebNov 30, 2016 · Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use. Further research is needed to define the appropriate role for sodium thiosulfate among emerging otoprotection strategies. WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among …

WebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced … WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status

WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... WebObjectives: To determine safety, feasibility, and preliminary activity of transtympanic injection of sodium thiosulfate (STS) against cisplatin-induced hearing loss (CIHL). …

WebJan 25, 2008 · Purpose: We determined if the potentially otoprotective agent sodium thiosulfate (STS) could be given 6 h after cisplatin without diminishing the …

WebSodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. To determine whether injection of thiosulfate would permit larger doses of cisplatin to … sims school softwareWebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe. Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing … sims school packageWebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss P.R. Brock and Others rcss columbiaWebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … rcss colomboWebApr 9, 2024 · In the COG ACCL0431, the hearing loss incidence rate was 28.6% in patients treated with sodium thiosulfate plus cisplatin compared with 56.4% in the cisplatin … rcss cranbrook bcWebFeb 1, 2024 · This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). You may also receive other medicine (eg, allergy medicine, steroid medicine) or … rcss deerfoot meadowsWebPEDMARK (sodium thiosulfate injection) is a sterile, preservative-free, clear, colorless solution in a single-dose vial for intravenous use with a pH between 7 and 9. Each vial contains the equivalent of 12.5 grams of sodium thiosulfate pentahydrate (provided as sodium thiosulfate anhydrous 8 grams) in 100 mL solution (125 mg/mL). rcs score respiratory