Lc3-interacting region lir

Author: nchd

August undefined, 2024

WebSimilar to FUNDC1, phosphorylation near the N-terminal LC3 interaction region (LIR) of Bnip3 and Nix stabilizes their interaction with LC3 to promote mitophagy (Poole et al., 2024;Rogov et al ... Web1 aug. 2013 · LIR-containing proteins include cargo receptors, members of the basal autophagy apparatus, proteins associated with vesicles and of their transport, Rab …

Molecules Free Full-Text LIR Motif-Containing Hyperdisulfide β ...

Web张慧芳，黄自能，陈蔚，孙林，刘伏友，肖力. 1中南大学湘雅二医院肾内科，长沙 410000. 自噬是消除聚集的蛋白质及受损细胞器的过程，对于缓解应激、维持细胞稳态及细胞分化等至关重要[1-2]。 Web6 feb. 2024 · LC3: microtubuleassociated protein 1A/1B-light chain 3; LIR: LC3-interacting region; BNIP3: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;NIX: NIP3-like protein X; FUNDC1: FUN14 domain-containing protein 1. kim fairchild

Role of mitophagy in the hallmarks of aging_参考网

WebThe four amino acid linear LC3 interaction region (LIR) is shown in bold in its broader amino acid context. (B) Surface representation of the LIR binding site of LC3B in complex with a pS177 OPTN peptide (cyan). Region 1 (orange) and region 2 (purple) are shown. Web22 okt. 2024 · Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Small Molecules Experimental Data & … Web12 mrt. 2024 · A variety of molecules involved in the autophagic pathway engage in specific interactions with a unique sequence motif referred to as the LIR (LC3-interacting region) motif. Although identification of conserved structural features of LIR motifs in complex with LC3-family members has established a canonical LIR motif, atypical conformations of … kim feather obituary

The LC3-conjugation machinery specifies cargo loading and …

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Web2 dagen geleden · TBC1D15 localized to damaged lysosomes via its C-terminal LC3-interacting region (LIR) motif, and its N terminus served as a platform to assemble the ALR machinery. Web31 mei 2024 · Thus, the LIR–LC3 interaction is essential for the formation, transport, and maturation of autophagosomes. Genetic mutations in LIR motifs may significantly alter … kim family genetic investigation pltwWeb10 mrt. 2024 · Using analytical gel filtration chromatography-based analyses, we further narrowed down the FIP200-binding region of Optineurin(33–209) to its LIR region, as the phosphomimetic S177E mutant of ... kimetsu no yaiba world tour

"Web13 mei 2024 · LC3-II is the lipidated, phosphatidylethanolamine (PE)-conjugated membrane-associated species of LC3, which undergoes cleavage and lipidation following autophagy induction. The authors found that LC3-II is associated with immunopurified EVs [ 14 ], and is located within the lumen of purified EVs as evidenced by a protease-protection assay. " - Lc3-interacting region lir

Lc3-interacting region lir

6HYO: Structure of ULK1 LIR motif bound to GABARAP - RCSB

WebThe four amino acid linear LC3 interaction region (LIR) is shown in bold in its broader amino acid context. (B) Surface representation of the LIR binding site of LC3B in complex with … Web16 mrt. 2012 · TP53INP1-LC3 interaction occurs via a functional LC3-interacting region (LIR). Inactivating mutations of this sequence abolish TP53INP1-LC3 interaction, …

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Web14 okt. 2024 · In addition, overexpression of wild type SQSTM1 dramatically promoted the degradation of NCOA4, but not the LIR (LC3-interacting region) deletion mutant SQSTM1ΔLIR, which is deficient in mediating selective autophagy (Figs. 2F and S6A). Web30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 …

WebSARs interact with autophagy-related (ATG)8 family proteins via sequence motifs called LC3-interacting region (LIR) motifs in vertebrates and Atg8-interacting motifs (AIMs) in yeast and plants. SARs can be divided into two broad groups: soluble or membrane bound. Web1 aug. 2013 · A main driving force has been the discovery of specific autophagy receptors that sequester cargo into forming autophagosomes (phagophores). At the heart of this selectivity lies the LC3-interacting region (LIR) motif, which ensures the targeting … Read Volume 126 Issue 15 of Journal of Cell Science. We are excited to …

Web2 jun. 2024 · In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs-interacting protein and find that NEK9 and its LC3-interacting region (LIR) are required for primary cilia formation.... Web3 jan. 2024 · The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR) motifs that bind to the LIR docking site (LDS) of …

Web19 mrt. 2024 · The most prominent interaction mode is between the LC3 interacting region (LIR), also called Atg8 interacting motif (AIM), binding to the LIR docking site (LDS) in Atg8 homologs. There are variants of these motifs like “half-LIRs” and helical LIRs.

Web1 jan. 2014 · Characteristics of the LC3-interacting region Many of the experimentally verified LC3-binding proteins contain a short hydrophobic LC3-interacting region (LIR), … kim family stranded in snowWeb1 sep. 2014 · The LC3 interaction region and UBA domain of NBR1 are required for pexophagy. ( A ) Schematic representation of NBR1. NBR1 contains a phox and Bem1 (PB1) domain (amino acid alignment positions at residue 1–86), coiled-coil (CC) domain (289–330), LC3-interacting region (LIR) (541–637 and 746–755), juxta-UBA domain … kim farlow milroy indianaWeb24 jun. 2024 · These receptors then bind to autophagosome membrane attached LC3 through their LC3-interacting regions (LIRs) to engage the autophagic machinery. ... Rendering the receptor inactive to function in selective autophagy even though its ability to interact with LC3 through the LIR was unaltered . kim evenson the big betWeb6 mei 2013 · We demonstrate that each of the human LC3 isoforms (LC3A, LC3B, and LC3C) interacts with Atg13 via the LC3 interacting region (LIR) of Atg13. Using X-ray … kimfandf gmail.comWeb23 nov. 2024 · We found that Trim5α binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a β … kim farmer town of independenceWebAtomic detail structural data for the mouse SQSTM1-LC3 interaction indicated that the actual interaction region is much shorter, mapping to a stretch of 11 conserved acidic and hydrophobic residues, the LC3 recognition sequence (LRS). 28 Similar conclusions were derived when structural data became available for the human SQSTM1-LC3 interaction. … kim fatica phoenixWeb30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 displays cytoprotective and adaptogenic properties to modulate cellular homeostasis and survivability against hypoxia-induced stress. kim farnsworth