WebCidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 … WebIf tolerated, a second liter may be administered over a 1- to 3-hour period at the start of or immediately following Cidofovir dihydrate infusion. Topical: Off-label route: An extemporaneously prepared gel may be prepared by a compounding pharmacy and applied topically for mucocutaneous infections (McElhiney 2006). Cidofovir dihydrate …
Vistide European Medicines Agency
Web21 jul. 2024 · INTRODUCTION. Cidofovir was the first nucleotide analog approved for clinical use. The drug has been employed almost exclusively to treat cytomegalovirus (CMV) infections in patients with the acquired immunodeficiency syndrome (AIDS) and transplant recipients. However, cidofovir is also used as a therapeutic option against other viral … Web25 dec. 2024 · Cidofovir is a nucleotide analogue used primarily to treat CMV retinitis in patients with AIDS. However, cidofovir is also used to treat a number of DNA viruses including adenovirus. The main toxicity of cidofovir is nephrotoxicity, which can manifest as AKI, proteinuria, or a Fanconi-type syndrome with proximal tubular dysfunction. my own initiative
Cidofovir Side Effects: Common, Severe, Long Term
Web14 mrt. 2024 · Cidofovir induced chromosomal aberrations in human peripheral blood lymphocytes in vitro without metabolic activation (S-9 fraction). At the 4 cidofovir levels (12.5 to 100 μg/ml) tested, the percentage of damaged metaphases and number of aberrations per cell increased in a concentration-dependent manner. WebCytomegalovirus (CMV) infection; treatment or preemptive therapy in immunocompromised patients (alternative agent): Infants, Children, and Adolescents: IV: 5 mg/kg/dose once … WebCidofovir is embryotoxic in rats and rabbits and at subtherapeutic dose levels. A significantly increased foetal incidence of external, soft tissue and skeletal anomalies occurred in rabbits at 1.0 mg/kg/day, which was also maternally toxic. There are no studies of cidofovir in pregnant women. my own insurance